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Antimicrob Agents Chemother. 2008 May;52(5):1834-6. doi: 10.1128/AAC.01347-07. Epub 2008 Feb 19.

A peptide with a ProGln C terminus in the human saliva peptidome exerts bactericidal activity against Propionibacterium acnes.

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  • 1Division of Dermatology, Department of Medicine, University of California, San Diego, and VA San Diego Healthcare Center, Rm. 3217A, 3350 La Jolla Village Drive, San Diego, CA, USA.


Nine proline-rich peptides ending with a proline-glutamine C terminus in a salivary peptidome were sequenced by matrix-assisted laser desorption ionization time of flight time of flight tandem mass spectrometry. A GPPPQGGRPQ peptide binds gram-positive Propionibacterium acnes and considerably inhibits bacterial growth. The peptide exhibiting innate immunity may be applied for treatment of various P. acnes-associated human diseases.

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