Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Learn Mem. 2008 Feb 19;15(3):106-11. doi: 10.1101/lm.806008. Print 2008 Mar.

GABA(A) receptors determine the temporal dynamics of memory retention.

Author information

  • 1School of Psychology, The University of New South Wales, Sydney 2052, Australia. g.mcnally@unsw.edu.au

Abstract

Four experiments studied the role of GABA(A) receptors in the temporal dynamics of memory retention. Memory for an active avoidance response was a nonmonotonic function of the retention interval. When rats were tested shortly (2 min) or some time (24 h) after training, retention was excellent, but when they were tested at intermediate intervals (1-4 h), retention was poor. Activity at GABA(A) receptors was critical for impairing memory retention at the intermediate intervals because injection of the GABA(A) receptor partial inverse agonist FG7142 prior to test significantly improved performance. These retention enhancing effects of FG7142 were dose-dependent and not due to any nonspecific effects of FG7142 on activity. Our results suggest that the temporal dynamics of memory retention may be caused by variations in neurotransmission through the GABA(A) receptor in the post-training period.

PMID:
18285469
[PubMed - indexed for MEDLINE]
PMCID:
PMC2275652
Free PMC Article

Images from this publication.See all images (4)Free text

Figure 1.
Figure 2.
Figure 3.
Figure 4.
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk