FEBS Lett. 2008 Apr 9;582(8):1271-5. Epub 2008 Feb 20.

A careful disorderliness in the proteome: sites for interaction and targets for future therapies.

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EMBL, Meyerhofstrasse 1, 69117 Heidelberg, Germany. russell@embl.de

Abstract

The community of scientists interested in studying intrinsically unstructured (or disordered) proteins has emerged in recent years. What began as a controversial idea has become an established phenomenon. The new, greater focus on proteins that are in some way normally unstructured promises to provide a greater understanding of protein function, particularly with respect to protein-protein interactions. These regions also offer new possibilities into how interactions can be targeted by small molecules.

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