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Nat Rev Genet. 2008 Apr;9(4):314-8. doi: 10.1038/nrg2316. Epub 2008 Feb 19.

The road to genome-wide association studies.

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  • Lewis-Sigler Institute for Integrative Genomics, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, New Jersey 08544, USA. leonid@genomics.princeton.edu


The recent crop of results from genome-wide association studies might seem like a sudden development. However, this blooming follows a long germination period during which the necessary concepts, resources and techniques were developed and assembled. Here, I look back at how the necessary pieces fell into place, focusing on the less well-chronicled days before the launch of the HapMap project, and speculate about future developments.

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