Curr Opin Chem Biol. 2008 Feb;12(1):11-7. Epub 2008 Mar 7.

The Sirtuin family: therapeutic targets to treat diseases of aging.

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Sirtris Pharmaceuticals, Inc., 790 Memorial Drive, Cambridge, MA 02139, USA. jmilne@sirtrispharma.com

Abstract

Sirtuins have emerged as therapeutic targets to treat age-related diseases. There are seven human Sirtuins (SIRT1-7) that display diversity in cellular localization and function. Growing evidence suggests that small-molecule activators of SIRT1 may counteract age-related afflictions such as type 2 diabetes. Alternatively, inhibitors of SIRT2 may be useful in the treatment of neurodegenerative diseases such as Parkinson's disease. Recent discoveries of small-molecule and protein modulators of Sirtuin deacetylation activity have provided enormous insight into the biological and molecular functions of Sirtuins and have validated their potential as therapeutics.

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