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FEBS Lett. 2008 Apr 9;582(8):1220-4. doi: 10.1016/j.febslet.2008.02.015. Epub 2008 Feb 20.

Interaction networks for systems biology.

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  • 1EMBL, Structural and Computational Biology Unit, Meyerhofstrasse 1, D-69117 Heidelberg, Germany.


Cellular functions are almost always the result of the coordinated action of several proteins, interacting in protein complexes, pathways or networks. Progress made in devising suitable tools for analysis of protein-protein interactions, have recently made it possible to chart interaction networks on a large-scale. The aim of this review is to provide a short overview of the most promising contributions of interaction networks to human biology, structural biology and human genetics.

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