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J Am Acad Dermatol. 2008 Mar;58(3):415-20. doi: 10.1016/j.jaad.2007.10.010.

Disease severity, scratching, and sleep quality in patients with atopic dermatitis.

Author information

  • 1Department of Pediatrics, National Jewish Medical and Research Center, Denver, Colorado 80206, USA. benderb@njc.org

Abstract

BACKGROUND:

The relationship between sleep quality and disease severity in patients with atopic dermatitis has not been clearly defined.

METHODS:

Sleep efficiency and scratching were measured over 2 nights by polysomnography, actigraphy, and self-report in 20 adults with atopic dermatitis. Tumor necrosis factor, interleukin (IL)-6, and IL-10 were assayed from a subset of 9 participants.

RESULTS:

Sleep measured by actigraphy and polysomnography were strongly associated with each other. Decreased sleep efficiency was associated with increasing disease severity, scratching, and IL-6. Self-reported sleep quality and quality of life were not significantly correlated with either objective sleep measure.

LIMITATIONS:

Results in this pilot study await confirmation in a larger investigation.

CONCLUSION:

Objective measures but not self-report documented that increasing severity of atopic dermatitis results in more scratching and declining sleep quality. Our data also suggest an important relationship between sleep and IL-6.

PMID:
18280338
[PubMed - indexed for MEDLINE]
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