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Br J Dermatol. 2008 May;158(5):1125-8. doi: 10.1111/j.1365-2133.2008.08463.x. Epub 2008 Feb 15.

Multiple aggressive squamous skin cancers in association with nonbullous congenital ichthyosiform erythroderma.

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  • 1Department of Dermatology, Churchill Hospital, Old Road, Headington, Oxford OX3 7LJ, UK.


Nonbullous congenital ichthyosiform erythroderma (NBCIE) is one of the autosomal recessive inherited non-syndromic ichthyoses and is currently diagnosed on clinical grounds alone. Skin cancer is not a recognized complication of NBCIE. We report here two NBCIE patients who have developed multiple aggressive nonmelanoma skin cancers, predominantly cutaneous squamous cell carcinoma. NBCIE may be a risk factor for skin cancer development.

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