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Rejuvenation Res. 2008 Feb;11(1):177-85. doi: 10.1089/rej.2007.0614.

Effect of senescence on macrophage polarization and angiogenesis.

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  • 1Department of Ophthalmology and Visual Sciences, Washington University, St. Louis School of Medicine, St. Louis, Missouri 63110, USA.


There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

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