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1: Rejuvenation Res. 2008 Feb;11(1):177-85.Click here to read Links

Effect of senescence on macrophage polarization and angiogenesis.

Dace DS, Apte RS.

Department of Ophthalmology and Visual Sciences, Washington University, St. Louis School of Medicine, St. Louis, Missouri 63110, USA.

There is mounting evidence that as the immune system ages, a progressive deterioration in normal function occurs. Termed immunosenescence, aging impacts both the innate and adaptive immune responses. This review discusses the age-related alterations in the innate immune system, with a specific focus on macrophages. The downstream effect of altered macrophage function on aberrant angiogenesis in the pathophysiology of age-related eye disease is also discussed.

PMID: 18279031 [PubMed - indexed for MEDLINE]