J Am Acad Dermatol. 1991 Apr;24(4):598-602.

A 12-month treatment of severe psoriasis with acitretin: results of a Canadian open multicenter study.

Murray HE, Anhalt AW, Lessard R, Schacter RK, Ross JB, Stewart WD, Geiger JM.

Source

Department of Pediatrics and Child Health, University of Manitoba, Winnipeg.

Abstract

Both etretinate and its principal metabolite, acitretin, are efficacious in the treatment of psoriasis. Because patients with severe psoriasis often require chronic therapy, this study was undertaken to determine the efficacy, tolerability, and safety of acitretin in patients on continuous treatment for 12 months. The initial daily dose of 50 mg was taken for 4 weeks. Thereafter the dose was increased or decreased by 10 mg at monthly intervals (10 to 70 mg) to produce the optimal response with minimal toxicity. Seventy percent of the patients who completed 12 months of treatment showed marked improvement. All patients experienced adverse reactions; dry lips, hair loss, skin peeling, pruritus, and nail disorders were the most frequent. Fourteen patients were withdrawn from the study because of one or more intolerable adverse reactions.

PMID:: 1827800; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Psoriasis - MedlinePlus Health Information

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Acitretin versus etretinate in severe psoriasis. A double-blind randomized Nordic multicenter study in 168 patients. [Acta Derm Venereol Suppl (Stoc...]
Acitretin versus etretinate in severe psoriasis. A double-blind randomized Nordic multicenter study in 168 patients.
Bjerke JR, Geiger JM. Acta Derm Venereol Suppl (Stockh). 1989; 146:206-7.
Efficiency of acitretin in combination with UV-B in the treatment of severe psoriasis. [Arch Dermatol. 1990]
Efficiency of acitretin in combination with UV-B in the treatment of severe psoriasis.
Ruzicka T, Sommerburg C, Braun-Falco O, Köster W, Lengen W, Lensing W, Letzel H, Meigel WN, Paul E, Przybilla B. Arch Dermatol. 1990 Apr; 126(4):482-6.
Benefit of progressively increasing doses during the initial treatment with acitretin in psoriasis. [Dermatologica. 1989]
Benefit of progressively increasing doses during the initial treatment with acitretin in psoriasis.
Berbis P, Geiger JM, Vaisse C, Rognin C, Privat Y. Dermatologica. 1989; 178(2):88-92.
Review Acitretin. A review of its pharmacology and therapeutic use. [Drugs. 1992]
Review Acitretin. A review of its pharmacology and therapeutic use.
Pilkington T, Brogden RN. Drugs. 1992 Apr; 43(4):597-627.
Review Risk: benefit ratio in the treatment of psoriasis with systemic retinoids. [Br J Dermatol. 1990]
Review Risk: benefit ratio in the treatment of psoriasis with systemic retinoids.
Halioua B, Saurat JH. Br J Dermatol. 1990 Jun; 122 Suppl 36:135-50.

See reviews... See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.

Recent activity

Clear Turn Off Turn On

A 12-month treatment of severe psoriasis with acitretin: results of a Canadian o...
A 12-month treatment of severe psoriasis with acitretin: results of a Canadian open multicenter study.
J Am Acad Dermatol. 1991 Apr ;24(4):598-602.

PubMed
Cognitive impairment with significant brain parenchymal volume loss following st...
Cognitive impairment with significant brain parenchymal volume loss following standard adjuvant chemotherapy in a patient with breast cancer.
Clin Adv Hematol Oncol. 2007 Dec ;5(12):985-7; discussion 987-8.

PubMed
Characterization of developmentally regulated and retina-specific nuclear protei...
Characterization of developmentally regulated and retina-specific nuclear protein binding to a site in the upstream region of the rat opsin gene.
J Biol Chem. 1991 May 25 ;266(15):9667-72.

PubMed
Changes in the prevalence of HIV-related behaviors and perceptions among 1832 in...
Changes in the prevalence of HIV-related behaviors and perceptions among 1832 injecting drug users in Sichuan, China.
Sex Transm Dis. 2008 Apr ;35(4):325-35.

PubMed
Variability among pediatric infectious diseases specialists in the treatment and...
Variability among pediatric infectious diseases specialists in the treatment and prevention of methicillin-resistant Staphylococcus aureus skin and soft tissue infections.
Pediatr Infect Dis J. 2008 Mar ;27(3):270-2.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: