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Nat Chem Biol. 2008 Mar;4(3):152-6. doi: 10.1038/nchembio0308-152.

Expanding chemical biology of 2-oxoglutarate oxygenases.

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  • 1Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford OX1 3TA, UK. christopher.schofield@chem.ox.ac.uk


Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.

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