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Eur J Cardiovasc Prev Rehabil. 2008 Feb;15(1):107-12. doi: 10.1097/HJR.0b013e3282f29aa6.

Regular exercise training compared with percutaneous intervention leads to a reduction of inflammatory markers and cardiovascular events in patients with coronary artery disease.

Author information

  • 1Department of Cardiology, Heart Center, University of Leipzig, Leipzig, Germany. waltherc@medizin.uni-leipzig.de

Abstract

BACKGROUND:

Chronic vascular inflammation may trigger ischemic events whereas regular physical exercise training (ET) has shown to be cardioprotective in patients with coronary artery disease (CAD). We investigated the impact of 2 years regular ET versus percutaneous intervention (PCI) on chronic inflammation and cardiovascular events.

METHODS AND RESULTS:

A total of 101 male patients with stable CAD and an indication for revascularization were prospectively randomized to regular ET (n=51) or PCI with stentimplantation (n=50). High-sensitive C-reactive protein and interleukin-6, exercise capacity and ischemic endpoints were analyzed at baseline and after 2 years. At 2 years maximal oxygen consumption (VO2 max) increased by 10% in the ET group (23.3+/-0.6 to 25.7+/-1.0 ml O2/kg/min; P=0.0171 versus baseline) versus 7% in the PCI group (22.3+/-0.8 to 23.9+/-1.2 ml O2/kg/min; P=0.4248). In a subgroup of patients, high-sensitive C-reactive protein levels and interleukin-6 levels were significantly reduced after ET by 41 and 18%, respectively, whereas no relevant changes were observed in the PCI group. Event-free survival rates after 24 months were 78% (ET) versus 62% (PCI) (P=0.039).

CONCLUSION:

In patients with stable coronary artery disease, regular physical exercise is associated with a reduction of inflammatory markers and ischemic events.

PMID:
18277195
[PubMed - indexed for MEDLINE]
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