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J Affect Disord. 2008 Sep;110(1-2):161-6. doi: 10.1016/j.jad.2007.12.227. Epub 2008 Feb 13.

Sequence of improvement in depressive symptoms across cognitive therapy and pharmacotherapy.

Author information

  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia, PA 19104, USA. sbhar@mail.med.upenn.edu.au

Abstract

BACKGROUND:

The authors examined the patterns of improvement in cognitive and vegetative symptoms of major depression in individuals treated with cognitive therapy (CT) or pharmacotherapy (PT).

METHOD:

Outpatients diagnosed with major depressive disorder (n=180) were randomized to receive either CT or PT. Cognitive and vegetative symptoms of major depression were measured by the Beck Depression Inventory-II at baseline and regularly throughout 16 weeks of treatment.

RESULTS:

Multivariate hierarchical linear modeling demonstrated the same patterns of change over time for cognitive and vegetative symptoms within CT and within PT.

LIMITATIONS:

Self-report measures may not be sufficiently specific to capture subtle differences in improvements between vegetative and cognitive symptoms.

CONCLUSIONS:

These results are consistent with Beck's [Beck, A.T., 1984, November. Cognition and theory [Letter to the editor]. Arch. Gen. Psychiatry 41, 1112-1114.] hypothesis that CT and PT have a similar site of action, which when targeted, results in changes in both cognitive and vegetative features.

PMID:
18276017
[PubMed - indexed for MEDLINE]
PMCID:
PMC2566850
Free PMC Article
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