The importance of prolonged binding to antigen-presenting cells for T cell fate decisions

Immunity. 2008 Feb;28(2):143-5. doi: 10.1016/j.immuni.2008.01.006.

Abstract

How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8(+) T cells encountering "nonsticky" antigen-presenting cells lacking intercellular adhesion molecule-1.

Publication types

  • Comment

MeSH terms

  • Animals
  • Antigen Presentation
  • Antigen-Presenting Cells / immunology*
  • Antigen-Presenting Cells / metabolism
  • CD8-Positive T-Lymphocytes / immunology*
  • CD8-Positive T-Lymphocytes / metabolism
  • Humans
  • Immunologic Memory
  • Intercellular Adhesion Molecule-1 / immunology
  • Intercellular Adhesion Molecule-1 / metabolism*
  • Lymphocyte Cooperation
  • Lymphocyte Function-Associated Antigen-1 / immunology
  • Lymphocyte Function-Associated Antigen-1 / metabolism*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Antigen, T-Cell / metabolism
  • Signal Transduction

Substances

  • Lymphocyte Function-Associated Antigen-1
  • Receptors, Antigen, T-Cell
  • Intercellular Adhesion Molecule-1