Abstract
How critical is it for T cells to stably arrest on antigen-presenting cells? In this issue of Immunity, Scholer et al. (2008) demonstrate profound effector and memory defects for CD8(+) T cells encountering "nonsticky" antigen-presenting cells lacking intercellular adhesion molecule-1.
MeSH terms
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Animals
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Antigen Presentation
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Antigen-Presenting Cells / immunology*
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Antigen-Presenting Cells / metabolism
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CD8-Positive T-Lymphocytes / immunology*
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CD8-Positive T-Lymphocytes / metabolism
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Humans
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Immunologic Memory
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Intercellular Adhesion Molecule-1 / immunology
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Intercellular Adhesion Molecule-1 / metabolism*
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Lymphocyte Cooperation
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Lymphocyte Function-Associated Antigen-1 / immunology
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Lymphocyte Function-Associated Antigen-1 / metabolism*
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Receptors, Antigen, T-Cell / immunology
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Receptors, Antigen, T-Cell / metabolism
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Signal Transduction
Substances
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Lymphocyte Function-Associated Antigen-1
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Receptors, Antigen, T-Cell
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Intercellular Adhesion Molecule-1