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Ann Clin Biochem. 2008 Jan;45(Pt 1):91-2. doi: 10.1258/acb.2007.007079.

Extent of bilirubin interference with Beckman creatinine methods.

Author information

  • 1Department of Chemical Pathology, Queensland Health Pathology Service (QHPS), Princess Alexandra Hospital, Ipswich Road, Woolloongabba, Queensland 4102, Australia. Goce_Dimeski@health.qld.gov.au

Abstract

BACKGROUND:

The aim of the study was to determine the extent of bilirubin interference on two different Beckman-Coulter creatinine methods used on the CX5 PRO/DxC 600 and the DxC 800 systems, respectively.

METHODS:

The Beckman methods were compared with a high-performance liquid chromatography (HPLC) method using 104 patient samples with creatinine concentrations <133 micromol/L and bilirubin concentrations of between 30 and 802 micromol/L.

RESULTS:

The linear regression analysis calculations expressing the relationship between bilirubin concentration and the observed difference between the Beckman and HPLC creatinine methods are: DxC800 creatinine M (modular or cup) method: r(2) 0.217, slope -0.023 and intercept 6.43; and DxC600 method: r(2) 0.7324, slope -0.0882 and intercept 12.01.

CONCLUSIONS:

There is significantly greater interference by bilirubin on the CX5 PRO/DxC 600 method, which can lead to inaccuracy in the calculation of the estimated glomerular filtration rate by the Modification of Diet in Renal Disease equation.

PMID:
18275681
[PubMed - indexed for MEDLINE]
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