J Med Chem. 2008 Mar 13;51(5):1108-10. Epub 2008 Feb 15.

Potent inhibitors of the hedgehog signaling pathway.

Brunton SA, Stibbard JH, Rubin LL, Kruse LI, Guicherit OM, Boyd EA, Price S.

Evotec, Oxfordshire, UK. shirley.brunton@evotec.com

A small family of phenyl quinazolinone ureas is reported as potent modulators of Hedgehog protein function. Preliminary SAR studies of the urea substituent led to a nanomolar Hedgehog antagonist.

PMID: 18275133 [PubMed - indexed for MEDLINE]

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