Plant Physiol Biochem. 2008 Mar;46(3):265-74. Epub 2008 Jan 3.

Structure, topology and function of the translocase of the outer membrane of mitochondria.

Perry AJ, Rimmer KA, Mertens HD, Waller RF, Mulhern TD, Lithgow T, Gooley PR.

Source

Department of Biochemistry and Molecular Biology, Bio21 Institute of Biotechnology and Molecular Science, University of Melbourne, Parkville, Victoria 3010, Australia.

Abstract

Proteins destined for the mitochondria required the evolution of specific and efficient molecular machinery for protein import. The subunits of the import translocases of the inner membrane (TIM) appear homologous and conserved amongst species, however the components of the translocase of the outer membrane (TOM) show extensive differences between species. Recently, bioinformatic and structural analysis of Tom20, an important receptor subunit of the TOM complex, suggests that this protein complex arose from different ancestors for plants compared to animals and fungi, but has subsequently converged to provide similar functions and analogous structures. Here we review the current knowledge of the TOM complex, the function and structure of the various subunits that make up this molecular machine.

PMID:: 18272380; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex. [J Mol Biol. 2002]
Protein translocase of the outer mitochondrial membrane: role of import receptors in the structural organization of the TOM complex.
Model K, Prinz T, Ruiz T, Radermacher M, Krimmer T, Kühlbrandt W, Pfanner N, Meisinger C. J Mol Biol. 2002 Feb 22; 316(3):657-66.
Effect of mutations in Tom40 on stability of the translocase of the outer mitochondrial membrane (TOM) complex, assembly of Tom40, and import of mitochondrial preproteins. [J Biol Chem. 2006]
Effect of mutations in Tom40 on stability of the translocase of the outer mitochondrial membrane (TOM) complex, assembly of Tom40, and import of mitochondrial preproteins.
Sherman EL, Taylor RD, Go NE, Nargang FE. J Biol Chem. 2006 Aug 11; 281(32):22554-65. Epub 2006 Jun 6.
A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments. [J Cell Biol. 2007]
A novel insertion pathway of mitochondrial outer membrane proteins with multiple transmembrane segments.
Otera H, Taira Y, Horie C, Suzuki Y, Suzuki H, Setoguchi K, Kato H, Oka T, Mihara K. J Cell Biol. 2007 Dec 31; 179(7):1355-63. Epub 2007 Dec 24.
Review How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane? [J Cell Biol. 2005]
Review How does the TOM complex mediate insertion of precursor proteins into the mitochondrial outer membrane?
Rapaport D. J Cell Biol. 2005 Nov 7; 171(3):419-23. Epub 2005 Oct 31.
Review Cooperation of translocase complexes in mitochondrial protein import. [J Cell Biol. 2007]
Review Cooperation of translocase complexes in mitochondrial protein import.
Kutik S, Guiard B, Meyer HE, Wiedemann N, Pfanner N. J Cell Biol. 2007 Nov 19; 179(4):585-91. Epub 2007 Nov 12.

See reviews... See all...

Cited by 4 PubMed Central articles

Phylogenetic analysis of mitochondrial outer membrane β-barrel channels. [Genome Biol Evol. 2012]
Phylogenetic analysis of mitochondrial outer membrane β-barrel channels.
Wojtkowska M, Jąkalski M, Pieńkowska JR, Stobienia O, Karachitos A, Przytycka TM, Weiner J 3rd, Kmita H, Makałowski W. Genome Biol Evol. 2012; 4(2):110-25. Epub 2011 Dec 8.
Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes. [J Biol Chem. 2010]
Conserved and novel functions for Arabidopsis thaliana MIA40 in assembly of proteins in mitochondria and peroxisomes.
Carrie C, Giraud E, Duncan O, Xu L, Wang Y, Huang S, Clifton R, Murcha M, Filipovska A, Rackham O, et al. J Biol Chem. 2010 Nov 12; 285(46):36138-48. Epub 2010 Sep 9.
Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner. [Mol Cell Biol. 2010]
Tom20 mediates localization of mRNAs to mitochondria in a translation-dependent manner.
Eliyahu E, Pnueli L, Melamed D, Scherrer T, Gerber AP, Pines O, Rapaport D, Arava Y. Mol Cell Biol. 2010 Jan; 30(1):284-94.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Structure, topology and function of the translocase of the outer membrane of mit...
Structure, topology and function of the translocase of the outer membrane of mitochondria.
Plant Physiol Biochem. 2008 Mar ;46(3):265-74. Epub 2008 Jan 3 .

PubMed
Globalization and the price decline of illicit drugs.
Globalization and the price decline of illicit drugs.
Int J Drug Policy. 2009 Jan ;20(1):48-61. Epub 2008 Feb 12 .

PubMed
Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus afte...
Effect of the proteolytic enzyme serrapeptase on swelling, pain and trismus after surgical extraction of mandibular third molars.
Int J Oral Maxillofac Surg. 2008 Mar ;37(3):264-8. Epub 2008 Feb 12 .

PubMed
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Pronociceptive response elicited by TRPA1 receptor activation in mice.
Neuroscience. 2008 Mar 18 ;152(2):511-20. Epub 2008 Jan 9 .

PubMed
Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in preg...
Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: a randomised controlled trial.
Midwifery. 2009 Dec ;25(6):649-53. Epub 2008 Feb 12 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: