ABSTRACT: BACKGROUND: Geographic Information Systems (GIS) describe the topography and chronology of events in a defined vector space. GIS may also be used for an integrated analysis of environmental and road-related risk factors for traffic accidents. METHODS: In a retrospective study, various features of 165 road crashes were linked to a GIS-generated digital map of an area close to a national highway in India. By overlay tools, clusters of accidents were identified, and color-coded according to accident mechanisms and injury patterns. RESULTS: Spatial analysis revealed a cluster with a high incidence of motorbike injuries resulting in fractures. Examination of the spot demonstrated the risky combination of a speed breaker and a broken traffic light. After fixing the light, no further accidents occurred at the site. CONCLUSION: GIS is a promising technology for geo-referencing accident data, and may be a valuable tool to identify areas of priority for injury prevention in India.