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Cell. 2008 Feb 8;132(3):434-48. doi: 10.1016/j.cell.2007.12.038.

A combinatorial code for CPE-mediated translational control.

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  • 1Centre for Genomic Regulation (CRG), UPF, C/Dr. Aiguader, 88, 08003 Barcelona, Spain.

Abstract

Cytoplasmic polyadenylation plays a key role in the translational control of mRNAs driving biological processes such as gametogenesis, cell-cycle progression, and synaptic plasticity. What determines the distinct time of polyadenylation and extent of translational control of a given mRNA, however, is poorly understood. The polyadenylation-regulated translation is controlled by the cytoplasmic polyadenylation element (CPE) and its binding protein, CPEB, which can assemble both translational repression or activation complexes. Using a combination of mutagenesis and experimental validation of genome-wide computational predictions, we show that the number and relative position of two elements, the CPE and the Pumilio-binding element, with respect to the polyadenylation signal define a combinatorial code that determines whether an mRNA will be translationally repressed by CPEB, as well as the extent and time of cytoplasmic polyadenylation-dependent translational activation.

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PMID:
18267074
[PubMed - indexed for MEDLINE]
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