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Cell. 2008 Feb 8;132(3):344-62. doi: 10.1016/j.cell.2008.01.020.

Shared principles in NF-kappaB signaling.

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  • 1Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06510, USA.

Abstract

The transcription factor NF-kappaB has served as a standard for inducible transcription factors for more than 20 years. The numerous stimuli that activate NF-kappaB, and the large number of genes regulated by NF-kappaB, ensure that this transcription factor is still the subject of intense research. Here, we attempt to synthesize some of the basic principles that have emerged from studies of NF-kappaB, and we aim to generate a more unified view of NF-kappaB regulation.

PMID:
18267068
[PubMed - indexed for MEDLINE]
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