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Malar J. 2008 Feb 11;7:30. doi: 10.1186/1475-2875-7-30.

Prevalence of contraindications to mefloquine use among USA military personnel deployed to Afghanistan.

Author information

  • 1Army Medical Surveillance Activity, 2900 Linden Lane, Suite 200, Silver Spring, MD 20910, USA. remington.nevin@us.army.mil

Abstract

BACKGROUND:

Mefloquine has historically been considered safe and well-tolerated for long-term malaria chemoprophylaxis, but its prescribing requires careful attention to rule out contraindications to its use, including a history of certain psychiatric and neurological disorders. The prevalence of these disorders has not been defined in cohorts of U.S. military personnel deployed to areas where long-term malaria chemoprophylaxis is indicated.

METHODS:

Military medical surveillance and pharmacosurveillance databases were utilized to identify contraindications to mefloquine use among a cohort of 11,725 active duty U.S. military personnel recently deployed to Afghanistan.

RESULTS:

A total of 9.6% of the cohort had evidence of a contraindication. Females were more than twice as likely as males to have a contraindication (OR = 2.48, P < 0.001).

CONCLUSION:

These findings underscore the importance of proper systematic screening prior to prescribing and dispensing mefloquine, and the need to provide alternatives to mefloquine suitable for long-term administration among deployed U.S. military personnel.

PMID:
18267019
[PubMed - indexed for MEDLINE]
PMCID:
PMC2259366
Free PMC Article
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