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J Antimicrob Chemother. 2008 Apr;61(4):805-9. doi: 10.1093/jac/dkn022. Epub 2008 Feb 8.

Antifungal susceptibility profile of clinical Fusarium spp. isolates identified by molecular methods.

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  • 1Servicio de Micología, Centro Nacional de Microbiología, Instituto de Salud Carlos III, 28220 Majadahonda, Madrid, Spain.

Abstract

OBJECTIVES:

To analyse the susceptibility pattern of a collection of Fusarium clinical isolates.

METHODS:

The antifungal susceptibility pattern of 67 isolates of Fusarium was analysed. Strains were identified by morphological and molecular methods by means of sequencing elongation factor alpha.

RESULTS AND CONCLUSIONS:

Six different species were identified. Fusarium solani was the most frequently isolated, followed by Fusarium oxysporum, Fusarium proliferatum and Fusarium verticilloides. Amphotericin B was the only drug with in vitro activity (range: 0.015-32 mg/L). The rest of the antifungals tested (itraconazole, voriconazole, ravuconazole, posaconazole and terbinafine) showed very poor activity against Fusarium, confirming the multiresistant nature of this genus.

PMID:
18263569
[PubMed - indexed for MEDLINE]
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