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Clin Neurophysiol. 2008 Apr;119(4):842-52. doi: 10.1016/j.clinph.2007.11.177. Epub 2008 Feb 7.

Non-provocative diagnostics of photosensitivity using visual evoked potentials.

Author information

  • 1Quantitative Imaging Group, Department of Imaging Science and Technology, Faculty of Applied Sciences, Delft University of Technology, Lorentzweg 1, 2628 CJ Delft, The Netherlands.

Abstract

OBJECTIVE:

Photosensitive epilepsy (PSE) is the most common form of reflex epilepsy. Usually, to find out whether a patient is sensitive, he/she is stimulated visually with, e.g. a stroboscopic light stimulus at variable frequency and intensity until a photo paroxysmal response (PPR) occurs. The research described in this work aims to find whether photosensitivity can be detected without provoking a PPR.

METHODS:

Twenty-two subjects, 15 with known photosensitivity, were stimulated with visual stimuli that did not provoke a PPR. Using an "evoked response representation", 18 features were analytically derived from EEG signals. Single- and multi-feature classification paradigms were applied to extract those features that separate best subjects with PSE from controls.

RESULTS:

Two variables in the "evoked response representation", a frequency term and a goodness of fit term to a particular template, appeared to be best suited to make a prediction about the photosensitivity of a subject.

CONCLUSIONS:

Evoked responses appear to carry information about potential PSE.

SIGNIFICANCE:

This result can be useful for screening patients for photosensitivity and it may also help to assess in a quantitative way the effectiveness of medical therapy.

[PubMed - indexed for MEDLINE]
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