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World J Surg Oncol. 2008 Feb 8;6:17. doi: 10.1186/1477-7819-6-17.

Regression of sporadic intra-abdominal desmoid tumour following administration of non-steroidal anti-inflammatory drug.

Author information

  • 1Department of Surgery, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan. keita2s@hyo-med.ac.jp

Abstract

BACKGROUND:

Desmoid tumours or fibromatoses are rare entities characterized by the benign proliferation of fibroblasts, which can be life-threatening due to their locally aggressive properties. Surgery is widely accepted as the first line of treatment for extra-abdominal desmoids; however, it is not recommended for intra-abdominal desmoids because of the high-risk of recurrence and difficulties with the operation. Here, we report on a patient with sporadic intra-abdominal desmoid tumours, who showed partial response following the intake of non-steroidal anti-inflammatory drugs.

CASE PRESENTATION:

A 73-year-old man presented with swelling and pain of the right leg. Computed tomography showed an abnormal multilocular soft-tissue mass (95 x 70 mm) in the right pelvis, which was revealed by biopsy to be a desmoid tumour. Immunohistochemical analysis showed that the tumour cells expressed vimentin, but not smooth-muscle actin, CD34, or desmin. Very few Ki-67-positive cells were found. Non-cytotoxic treatment with etodolac (200 mg/day) was chosen because of the patient's age, lack of bowel obstruction, and the likelihood of prostate cancer. Two years after the commencement of non-steroidal anti-inflammatory drug administration, computed tomography showed a decrease in tumour size (63 x 49 mm), and the disappearance of intratumoural septa.

CONCLUSION:

Our case report suggests that non-steroidal anti-inflammatory drug treatment should be taken into consideration for use as first-line treatment in patients with sporadic intra-abdominal desmoid tumours.

PMID:
18257933
[PubMed - indexed for MEDLINE]
PMCID:
PMC2270274
Free PMC Article

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