Laryngoscope. 1991 Mar;101(3):225-9.

Menière's disease: an immune complex-mediated illness?

Derebery MJ, Rao VS, Siglock TJ, Linthicum FH, Nelson RA.

Source

House Ear Clinic, Los Angeles, CA.

Abstract

The cause of Menière's disease is unknown. Recent clinical research suggests that one etiology is immune-mediated damage to the inner ear. The diagnosis of autoimmune Menière's syndrome is largely based on history, response to steroids, or results of nonspecific laboratory tests such as serological studies. Polyethylene glycol (PEG) assay was used to determine levels of circulating immune complexes (CIC) in 30 patients with Menière's disease and 20 control subjects. Patients with Menière's disease had a statistically significant elevation of serum circulating immune complexes when compared to the control group. This suggests that CICs may be involved in the pathogenesis of Menière's disease, either as a direct cause of damage, or as a by-product of an underlying autoimmune abnormality. Therapeutic implications include use of plasmapheresis to remove the complexes or CIC monitoring to serve as a marker for treatment efficacy.

Comment in

Laryngoscope. 1991 Aug;101(8):915.

PMID:: 1825685; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

Antigen-Antibody Complex

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Cited by 2 PubMed Central articles

High prevalence of systemic autoimmune diseases in patients with Menière's disease. [PLoS One. 2011]
High prevalence of systemic autoimmune diseases in patients with Menière's disease.
Gazquez I, Soto-Varela A, Aran I, Santos S, Batuecas A, Trinidad G, Perez-Garrigues H, Gonzalez-Oller C, Acosta L, Lopez-Escamez JA. PLoS One. 2011; 6(10):e26759. Epub 2011 Oct 28.
Polymorphisms of CD16A and CD32 Fcγ receptors and circulating immune complexes in Ménière's disease: a case-control study. [BMC Med Genet. 2011]
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Lopez-Escamez JA, Saenz-Lopez P, Gazquez I, Moreno A, Gonzalez-Oller C, Soto-Varela A, Santos S, Aran I, Perez-Garrigues H, Ibañez A, et al. BMC Med Genet. 2011 Jan 5; 12:2. Epub 2011 Jan 5.

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