Intermediate filaments in smooth muscle

Am J Physiol Cell Physiol. 2008 Apr;294(4):C869-78. doi: 10.1152/ajpcell.00154.2007. Epub 2008 Feb 6.

Abstract

The intermediate filament (IF) network is one of the three cytoskeletal systems in smooth muscle. The type III IF proteins vimentin and desmin are major constituents of the network in smooth muscle cells and tissues. Lack of vimentin or desmin impairs contractile ability of various smooth muscle preparations, implying their important role for smooth muscle force development. The IF framework has long been viewed as a fixed cytostructure that solely provides mechanical integrity for the cell. However, recent studies suggest that the IF cytoskeleton is dynamic in mammalian cells in response to various external stimulation. In this review, the structure and biological properties of IF proteins in smooth muscle are summarized. The role of IF proteins in the modulation of smooth muscle force development and redistribution/translocation of signaling partners (such as p130 Crk-associated substrate, CAS) is depicted. This review also summarizes our latest understanding on how the IF network may be regulated in smooth muscle.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Biomechanical Phenomena
  • Humans
  • Intermediate Filament Proteins / chemistry
  • Intermediate Filament Proteins / physiology*
  • Intermediate Filaments / chemistry
  • Intermediate Filaments / physiology*
  • Muscle, Smooth / chemistry
  • Muscle, Smooth / cytology*
  • Myocytes, Smooth Muscle / cytology*
  • Myocytes, Smooth Muscle / physiology*
  • Signal Transduction

Substances

  • Intermediate Filament Proteins