Gen Dent. 2008 Jan-Feb;56(1):96-102; quiz 103-4, 111-2.

Osteonecrosis of the jaw: balancing the benefits and risks of oral bisphosphonate treatment for osteoporosis.

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University of Pennsylvania School of Dental Medicine, Philadelphia, USA.

Abstract

Osteoporosis is a major public health problem. Oral bisphosphonates are effective for reducing the risk of osteoporotic fractures and are an important treatment option for patients at risk for this condition. Osteonecrosis of the jaw (ONJ) is uncommon among cancer patients who are receiving high-dose intravenous bisphosphonates and rarely is seen among patients who are taking oral bisphosphonates for osteoporosis. Dentists play an important role in discussing the implications of the overall dental and medical treatment plans with both patients and physicians. The low risk of ONJ with oral bisphosphonates should be balanced against the benefits of osteoporosis therapy.

PMID:: 18254568; [PubMed - indexed for MEDLINE]

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Diphosphonates

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Review A review of the literature on osteonecrosis of the jaw in patients with osteoporosis treated with oral bisphosphonates: prevalence, risk factors, and clinical characteristics. [Clin Ther. 2007]
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Cited by 2 PubMed Central articles

A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis. [Fibrogenesis Tissue Repair. 2010]
A novel soft-tissue in vitro model for bisphosphonate-associated osteonecrosis.
Scheper M, Chaisuparat R, Cullen K, Meiller T. Fibrogenesis Tissue Repair. 2010 Apr 1; 3:6. Epub 2010 Apr 1.
Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis. [Br J Haematol. 2009]
Effect of zoledronic acid on oral fibroblasts and epithelial cells: a potential mechanism of bisphosphonate-associated osteonecrosis.
Scheper MA, Badros A, Chaisuparat R, Cullen KJ, Meiller TF. Br J Haematol. 2009 Mar; 144(5):667-76. Epub 2008 Nov 20.

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