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Chem Commun (Camb). 2008 Feb 21;(7):883-5. doi: 10.1039/b716390h. Epub 2007 Dec 21.

Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.

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  • 1Department of Biochemistry, School of Medicine, Vanderbilt University, Nashville, TN 37232, USA.

Abstract

The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.

PMID:
18253536
[PubMed - indexed for MEDLINE]
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