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Skin Pharmacol Physiol. 2008;21(2):106-10. doi: 10.1159/000114871. Epub 2008 Feb 5.

Investigation of the anti-inflammatory potential of Aloe vera gel (97.5%) in the ultraviolet erythema test.

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  • 1Department of Dermatology, University Medical Center Freiburg, Freiburg, Germany.

Abstract

BACKGROUND:

Aloe vera is a natural product that is frequently used in soothing skin care products such as aftersun lotions. In the present study we aimed to explore the anti-inflammatory potential of a highly concentrated A. vera gel in the UV erythema test in vivo.

METHODS:

40 volunteers with skin types II and III were included in the randomized, double-blind, placebo-controlled, phase III monocenter study. Test areas on the back were irradiated with the 1.5-fold minimal erythema dose of UVB. Subsequently, the test areas were treated occlusively on 2 subsequent days with A. vera gel (97.5%), the positive controls (0.25% prednicarbate, 1% hydrocortisone in placebo gel and 1% hydrocortisone cream) and a placebo gel. Erythema values were determined photometrically after 24 and 48 h.

RESULTS:

A. vera gel (97.5%) significantly reduced UV-induced erythema after 48 h, being superior to 1% hydrocortisone in placebo gel. In contrast, 1% hydrocortisone in cream was more efficient than A. vera gel.

CONCLUSIONS:

In this study after 48 h the A. vera gel (97.5%) displayed some anti-inflammatory effects superior to those of 1% hydrocortisone in placebo gel. The A. vera gel tested here might be useful in the topical treatment of inflammatory skin conditions such as UV-induced erythema.

(c) 2008 S. Karger AG, Basel

PMID:
18253066
[PubMed - indexed for MEDLINE]
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