OBJECTIVE: To report a technique for open reduction and internal fixation of scapulohumeral joint luxation in large animals, and outcome. STUDY DESIGN: Clinical case reports. ANIMALS: Mature alpacas (n=3) and immature miniature steer (1). METHODS: Shoulder joint luxation was diagnosed by physical examination and confirmed by radiography. Open reduction was performed with internal fixation using lateral tension band sutures. RESULTS: Animals maintained shoulder joint reduction and were sound with radiographically normal shoulder joints (n=2) and normal range of motion without appreciable gait abnormalities (4) at follow-up 8-36 months later. CONCLUSIONS: In contrast to previous reports of open reduction with internal fixation of shoulder joint luxation in large animals, open reduction and use of lateral scapulohumeral tension sutures resulted in functionally normal shoulder joints. CLINICAL RELEVANCE: Stabilization of the shoulder joint with lateral scapulohumeral tension sutures after open reduction is effective, technically simple, and should be considered in large animal species weighing <100 kg.