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    Antimicrob Agents Chemother. 2008 Apr;52(4):1542-4. Epub 2008 Feb 4.

    Antiretroviral therapy with a twice-daily regimen containing 400 milligrams of indinavir and 100 milligrams of ritonavir in human immunodeficiency virus type 1-infected women during pregnancy.

    Ghosn J, De Montgolfier I, Cornélie C, Dominguez S, Pérot C, Peytavin G, Marcelin AG, Pauchard M, Ouagari Z, Bonmarchand M, Agher R, Calvez V, Bricaire F, Dommergues M, Katlama C, Tubiana R.

    Source

    AP-HP, Department of Infectious Diseases, Pitie-Salpetriere Hospital, 47 Boulevard de l'Hôpital, 75013 Paris, France. jade.ghosn@bct.aphp.fr

    Abstract

    We evaluated the safety and efficacy of a twice daily regimen containing 400 mg of indinavir and 100 mg of ritonavir in 32 human immunodeficiency virus (HIV)-infected women during pregnancy. The median indinavir trough concentration was 208 ng/ml during the third trimester. At delivery, 26 of 28 women on indinavir-ritonavir had HIV RNA levels of <200 copies/ml. No infant was HIV infected. These data are encouraging for the use of this combination for prevention of mother-to-child transmission of HIV.

    PMID:
    18250187
    [PubMed - indexed for MEDLINE]
    PMCID:
    PMC2292558
    Free PMC Article

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