Cell Metab. 2008 Feb;7(2):101-3.

Phosphatases at the heart of FoxO metabolic control.

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McGill Cancer Centre, McGill University, Montréal, PQ, H3G 1Y6, Canada. michel.tremblay@mcgill.ca <michel.tremblay@mcgill.ca>

Abstract

FoxO transcription factors contribute to cardiac muscle remodeling and insulin signaling, but how they link insulin resistance and maladaptive heart hypertrophy remains unknown. A new study by Ni et al. (2007) shows that sustained activation of FoxO1 or FoxO3 in cardiomyocytes selectively enhances the activity of Akt/PKB and reduces insulin signaling through inhibition of calcineurin and PP2A.

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FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases. [Proc Natl Acad Sci U S A. 2007]
FoxO transcription factors activate Akt and attenuate insulin signaling in heart by inhibiting protein phosphatases.
Ni YG, Wang N, Cao DJ, Sachan N, Morris DJ, Gerard RD, Kuro-O M, Rothermel BA, Hill JA. Proc Natl Acad Sci U S A. 2007 Dec 18; 104(51):20517-22. Epub 2007 Dec 12.
Foxo transcription factors blunt cardiac hypertrophy by inhibiting calcineurin signaling. [Circulation. 2006]
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Ni YG, Berenji K, Wang N, Oh M, Sachan N, Dey A, Cheng J, Lu G, Morris DJ, Castrillon DH, et al. Circulation. 2006 Sep 12; 114(11):1159-68. Epub 2006 Sep 4.
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Evans-Anderson HJ, Alfieri CM, Yutzey KE. Circ Res. 2008 Mar 28; 102(6):686-94. Epub 2008 Jan 24.
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Cited by 9 PubMed Central articles

Metabolic stress-induced activation of FoxO1 triggers diabetic cardiomyopathy in mice. [J Clin Invest. 2012]
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