Curr Opin Cell Biol. 2008 Feb;20(1):77-84. Epub 2008 Jan 30.

Polo and Aurora kinases: lessons derived from chemical biology.

Source

Faculty of Life Sciences, University of Manchester, Michael Smith Building, Manchester, UK. stephen.taylor@manchester.ac.uk

Abstract

During the cell division cycle, mitotic entry, spindle assembly, chromosome segregation, and cytokinesis must all be carefully coordinated to ensure that the two daughter cells inherit all the genetic material required for further growth and development. Central to this coordination are several protein kinases including Aurora A, Aurora B, and the Polo-like kinase, Plk1. A number of small-molecule Aurora and Plk1 inhibitors have been developed because these kinases are seen as attractive anticancer drug targets. These inhibitors are now being widely used as chemical biology tools to understand how these kinases ensure faithful genome transmission.

PMID:: 18249108; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus. [Cell Cycle. 2011]
Polo-like kinase 1 regulates activation of AMP-activated protein kinase (AMPK) at the mitotic apparatus.
Vazquez-Martin A, Oliveras-Ferraros C, Cufí S, Menendez JA. Cell Cycle. 2011 Apr 15; 10(8):1295-302. Epub 2011 Apr 15.
Polo-like kinase controls vertebrate spindle elongation and cytokinesis. [PLoS One. 2007]
Polo-like kinase controls vertebrate spindle elongation and cytokinesis.
Brennan IM, Peters U, Kapoor TM, Straight AF. PLoS One. 2007 May 2; 2(5):e409. Epub 2007 May 2.
Aurora B kinase activation requires survivin priming phosphorylation by PLK1. [J Mol Cell Biol. 2011]
Aurora B kinase activation requires survivin priming phosphorylation by PLK1.
Chu Y, Yao PY, Wang W, Wang D, Wang Z, Zhang L, Huang Y, Ke Y, Ding X, Yao X. J Mol Cell Biol. 2011 Aug; 3(4):260-7. Epub 2010 Dec 9.
Review Shared and separate functions of polo-like kinases and aurora kinases in cancer. [Nat Rev Cancer. 2010]
Review Shared and separate functions of polo-like kinases and aurora kinases in cancer.
Lens SM, Voest EE, Medema RH. Nat Rev Cancer. 2010 Dec; 10(12):825-41. Epub 2010 Nov 24.
Review Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy. [Nat Rev Drug Discov. 2010]
Review Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy.
Strebhardt K. Nat Rev Drug Discov. 2010 Aug; 9(8):643-60.

See reviews... See all...

Cited by 22 PubMed Central articles

Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair. [Mol Cell. 2012]
Plk1 and CK2 act in concert to regulate Rad51 during DNA double strand break repair.
Yata K, Lloyd J, Maslen S, Bleuyard JY, Skehel M, Smerdon SJ, Esashi F. Mol Cell. 2012 Feb 10; 45(3):371-83.
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner. [Cell. 2011]
Nuclear PTEN regulates the APC-CDH1 tumor-suppressive complex in a phosphatase-independent manner.
Song MS, Carracedo A, Salmena L, Song SJ, Egia A, Malumbres M, Pandolfi PP. Cell. 2011 Jan 21; 144(2):187-99.
Review APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity. [Cell Cycle. 2010]
Review APC/C-Cdh1: from cell cycle to cellular differentiation and genomic integrity.
Qiao X, Zhang L, Gamper AM, Fujita T, Wan Y. Cell Cycle. 2010 Oct 1; 9(19):3904-12. Epub 2010 Oct 11.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Polo and Aurora kinases: lessons derived from chemical biology.
Polo and Aurora kinases: lessons derived from chemical biology.
Curr Opin Cell Biol. 2008 Feb ;20(1):77-84. Epub 2008 Jan 30 .

PubMed
WISE-2005: supine treadmill exercise within lower body negative pressure and fly...
WISE-2005: supine treadmill exercise within lower body negative pressure and flywheel resistive exercise as a countermeasure to bed rest-induced bone loss in women during 60-day simulated microgravity.
Bone. 2008 Mar ;42(3):572-81. Epub 2007 Dec 14 .

PubMed
Different genes govern Yersinia pestis pathogenicity in Caenorhabditis elegans a...
Different genes govern Yersinia pestis pathogenicity in Caenorhabditis elegans and human lice.
Microb Pathog. 2008 May ;44(5):435-7. Epub 2007 Dec 14 .

PubMed
Multifocal adult rhabdomyoma of the head and neck: a case report and literature ...
Multifocal adult rhabdomyoma of the head and neck: a case report and literature review.
Auris Nasus Larynx. 2008 Jun ;35(2):313-7. Epub 2008 Jan 14 .

PubMed
Postnatal induction and localization of R7BP, a membrane-anchoring protein for r...
Postnatal induction and localization of R7BP, a membrane-anchoring protein for regulator of G protein signaling 7 family-Gbeta5 complexes in brain.
Neuroscience. 2008 Feb 19 ;151(4):969-82. Epub 2007 Dec 8 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Polo and Aurora kinases: lessons derived from chemical biology.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 22 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information