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FEMS Microbiol Rev. 2008 Mar;32(2):361-85. doi: 10.1111/j.1574-6976.2007.00095.x. Epub 2008 Jan 29.

Penicillin-binding proteins and beta-lactam resistance.

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  • 1Laboratoire d'Ingénierie des Macromolécules, Institut de Biologie Structurale Jean-Pierre Ebel, UMR 5075-CNRS, CEA, Université Joseph Fourier, Grenoble, France.

Abstract

A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even within this narrow focus, a great variety of strategies have been uncovered such as the acquisition of an additional low-affinity PBP, the overexpression of an endogenous low-affinity PBP, the alteration of endogenous PBPs by point mutations or homologous recombination or a combination of the above.

PMID:
18248419
[PubMed - indexed for MEDLINE]
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