Curr Opin Investig Drugs. 2008 Feb;9(2):201-9.

Ceftaroline fosamil, a cephalosporin derivative for the potential treatment of MRSA infection.

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Columbia University School of Medicine, 1090 Amsterdam Avenue, St Lukes Roosevelt Hospital Center, New York, NY 10025, USA.

Abstract

Forest Laboratories (following its acquisition of Cerexa Inc, a spin-out from Peninsula Pharmaceuticals Inc), under license from Takeda, is developing ceftaroline fosamil, an N-phosphono prodrug of ceftaroline, a derivative of a fourth-generation cephalosporin, for the potential treatment of methicillin-resistant Staphylococcus aureus infection. Phase III clinical trials evaluating ceftaroline fosamil for community acquired pneumonia and complicated skin and skin structure infections are underway.

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