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Semin Fetal Neonatal Med. 2008 Apr;13(2):69-75. doi: 10.1016/j.siny.2007.12.007. Epub 2008 Feb 4.

Non-invasive fetal sex determination: impact on clinical practice.

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  • 1International Blood Group Reference Laboratory, Southmead Road, Bristol, UK.


Prenatal fetal sex determination is undertaken in women at high risk of serious genetic disorders affecting a specific sex. Traditionally, this is undertaken by invasive testing, usually chorionic villus sampling, which carries a risk of miscarriage of around 1%. The identification of cell-free fetal DNA in the maternal circulation has allowed the development of 'non-invasive prenatal diagnostic tests', which permit fetal sex determination without risk to the pregnancy.

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