Referral Center for Demyelinating Diseases of the Central Nervous System, University Department of Neurology, Zagreb School of Medicine and University Hospital Center, Zagreb, Croatia.
A patient is described who presented with focal brain lesion considered to be a tumor and later developed disseminated white matter disease. After 21 years of clinical and MRI follow up, the diagnosis of isolated neurosarcoidosis was confirmed by histology. The follow up of more than 21 years in this patient supported the existence of isolated neurosarcoidosis as a separate disease entity.