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J Reprod Immunol. 2008 Jul;78(2):85-93. doi: 10.1016/j.jri.2007.11.002. Epub 2008 Feb 19.

Anti-apoptotic seminal vesicle protein IV inhibits cell-mediated immunity.

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  • 1Institute of Neurobiology and Molecular Medicine (INMM), CNR, Area Ricerca Roma Tor Vergata, Via del Fosso del Cavaliere 100, Rome, Italy.


The in vitro effect of seminal vesicle protein IV (SV-IV) on the cytotoxic activity of human natural or acquired cellular immunity has been investigated by standard immunological procedures, a (51)Cr-release cytotoxicity assay, and labeled-ligand binding experiments. The data obtained demonstrate that: (1) fluoresceinated or [(125)I]-labeled SV-IV binds specifically to the surface of human purified non-adherent mononuclear cells (NA-MNC); (2) SV-IV suppresses the cytotoxicity of natural killer (NK) cells against K562 target cells, that of IL-2-stimulated NK (LAK) cells against DAUDI target cells, and that of VEL antigen-sensitized cytotoxic T lymphocytes (CTLs) against VEL target cells; (3) treatment of K562 target cells alone with SV-IV decreases their susceptibility to NK-induced lysis. These findings indicate that the protein SV-IV has a marked in vitro inhibitory effect on NK, LAK and CTL cytotoxicity, providing a better understanding of its immune regulatory functions.

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