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Mol Cell. 2008 Feb 1;29(2):151-2. doi: 10.1016/j.molcel.2008.01.005.

GU-rich RNA: expanding CUGBP1 function, broadening mRNA turnover.

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  • 1Laboratory of Cellular and Molecular Biology, National Institute on Aging-Intramural Research Program, National Institutes of Health, Baltimore, MD 21224, USA.


In this issue of Molecular Cell, Vlasova et al. (2008) identify the GU-rich element (GRE) as a novel, widespread, degradation-promoting sequence through which the RNA-binding protein CUGBP1 elicits mRNA decay.

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