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Bioorg Med Chem. 2008 Mar 15;16(6):3387-94. doi: 10.1016/j.bmc.2007.12.003. Epub 2007 Dec 8.

Structure and estrogenic activity of new lignans from Iryanthera lancifolia.

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  • 1Instituto Universitario de Bio-Orgánica Antonio González, Avda. Astrofísico Fco, Sánchez 2, 38206 La Laguna, Tenerife, Spain.

Abstract

Five new dibenzylbutane type lignans (1-5) were isolated from the stem bark of Iryanthera lancifolia. Their structures were determined by extensive 1D and 2D NMR spectroscopic studies and chemical evidence. Seventeen of the isolated compounds were tested for their estrogenic activities in the estrogen responsive human breast cancer cell line MCF-7 BUS using the E-Screen proliferation assay. Cell proliferation was evaluated by the SRB assay to calculate the estrogenic parameters. The majority of the compounds induced a mitogenic response. This effect, given as Relative Proliferative Effect (RPE) to reference estrogen 17beta-estradiol (E(2)), ranged between 14% and 84%.

PMID:
18242997
[PubMed - indexed for MEDLINE]
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