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Am J Infect Control. 2008 Feb;36(1):70-3. doi: 10.1016/j.ajic.2007.01.012.

Fluoroquinolone resistance in pediatric bloodstream infections because of Escherichia coli and Klebsiella species.

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  • 1Division of Infectious Diseases, Department of Pediatrics, Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.


In pediatric bloodstream infections with fluoroquinolone (FQ)-resistant Escherichia coli and Klebsielia species, we noted an association between FQ resistance and extended-spectrum beta-lactamase (ESBL) production (OR, 12; 95% CI: 2.28-83.8). A case control study revealed no significant risk factors (including prior antibiotic use) for FQ resistance among ESBL E coli and Klebsiella species (ESBL-EK).

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