Hitting HIV where it hides. [Retrovirology. 2008]

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1: Retrovirology. 2008 Feb 1;5:15. Links

Hitting HIV where it hides.

Dayton AI.

The recent finding that inhibitors of PI3/Akt can sensitize HIV infected macrophages to oxidative stress-induced cell death suggest a potential new therapeutic approach to targeting HIV reservoirs.

PMID: 18241337 [PubMed - indexed for MEDLINE]

PMCID: PMC2253557

Akt inhibitors as an HIV-1 infected macrophage-specific anti-viral therapy.
Retrovirology. 2008 Jan 31; 5:11. Epub 2008 Jan 31.

[Retrovirology. 2008]
Infection of human immunodeficiency virus and intracellular viral Tat protein exert a pro-survival effect in a human microglial cell line.
J Mol Biol. 2007 Feb 9; 366(1):67-81. Epub 2006 Nov 10.

[J Mol Biol. 2007]
Differential modulation of Akt/glycogen synthase kinase-3beta pathway regulates apoptotic and cytoprotective signaling responses.
J Biol Chem. 2008 May 30; 283(22):15469-78. Epub 2008 Apr 3.

[J Biol Chem. 2008]
ReviewActivation of the PI3-K/AKT pathway and implications for radioresistance mechanisms in head and neck cancer.
Lancet Oncol. 2008 Mar; 9(3):288-96.

[Lancet Oncol. 2008]
ReviewThe PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.
Curr Cancer Drug Targets. 2008 Feb; 8(1):7-18.

[Curr Cancer Drug Targets. 2008]
» See reviews... | » See all...

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