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1: J Calif Dent Assoc. 2007 Dec;35(12):865-9.Links

TGF-beta signaling and aplasia cutis congenita: proposed animal model.

Zehnaly A, Hosokawa R, Urata M, Chai Y.

University of Southern California, School of Dentistry, USA. zehnaly@usc.edu

TGF-beta plays a role in cell migration, proliferation, and differentiation during embryonic development. This study investigated the effect of neural crest- or mesodermspecific loss of TGF-beta type II receptor in mice. These conditional knockout mice both exhibit skin defects of the skull associated with an underlying bone defect, a phenotype consistent with the human disorder aplasia cutis congenita. The authors suggest that TGF-3 type II receptor gene is a candidate gene for aplasia cutis congenita.

PMID: 18240750 [PubMed - indexed for MEDLINE]