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BMC Med Genomics. 2008 Jan 31;1:2. doi: 10.1186/1755-8794-1-2.

Microarray analysis in B cells among siblings with/without MS - role for transcription factor TCF2.

Author information

  • 1Multiple Sclerosis Specialty Care, Kansas Neurological Consultants, PA, Wichita, KS 67218, USA. javasarala@yahoo.com

Abstract

BACKGROUND:

We investigated if global gene expression and transcription networks in B-lymphocytes of siblings with multiple sclerosis (MS) were different from healthy siblings.

RESULTS:

Using virus-transformed immortalized B cells and human whole genome bioarrays with validation using RT-qPCR, we found that in siblings with MS, genes for CXCL10, serpin B1 and FUT4 were up regulated whereas CDC5L, TNFRSF19 and HLA-DR were down regulated, among others; transcription analysis showed two intersecting clusters of transcriptional factors - the larger, governed by the upregulated transcription factor 2 (TCF2) and the smaller network regulated by the downregulated CDC5L.

CONCLUSION:

No study has linked TCF2 to MS and to better understand the role of TCF2 in MS, studies in larger cohorts are required.

PMID:
18237449
[PubMed]
PMCID:
PMC2227948
Free PMC Article
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