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Exp Toxicol Pathol. 2008 Apr;59(6):425-30. doi: 10.1016/j.etp.2007.10.010. Epub 2008 Jan 29.

Induction of COX-2 expression by acrolein in the rat model of hemorrhagic cystitis.

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  • 1Department of Physiology and Pharmacology, Federal University of Ceara, Rua Coronel Nunes de Melo, 1315, Rodolfo Teofilo, 60430-270 fortaleza, CE, Brazil.



Acrolein (ACR) is a urinary metabolite of cyclophosphamide (CPS) and ifosfamide (IFS), which has been demonstrated to be the causative agent of hemorrhagic cystitis (HC), induced by these compounds. In this study, we investigate the participation of cyclooxygenase-2 (COX-2) on ACR-induced HC.


Male Wistar rats (150-200g; six rats per group) were treated with distilled water or intravesical ACR and analyzed by changes in bladder wet weight, macroscopic and microscopic parameters and COX-2 expression.


COX-2 immunohistochemical expression was significant 12h after ACR administration mainly in subepithelial cells. ACR injection also alters some macroscopic and microscopic parameters in bladder of rats analyzed by Gray's criteria.


COX-2 participates in the pathogenesis of ACR-induced HC first seen 12h after initial contact between ACR and urothelium.

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