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    Hum Pathol. 2008 Jun;39(6):910-6. Epub 2008 Jan 30.

    Expression of the translation initiation factors eIF-4E and eIF-2* is frequently increased in neoplastic cells of Hodgkin lymphoma.

    Rosenwald IB, Koifman L, Savas L, Chen JJ, Woda BA, Kadin ME.

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    Department of Pathology, New England Medical Center, Boston, MA 02111, USA. irozenvald@tufts-nemc.org

    Abstract

    The rate of protein synthesis is regulated in part by 2 key translation initiation factors, eIF-4E and eIF-2*. The expression and activity of both factors are increased transiently when normal resting cells are stimulated to proliferate, but they are constitutively elevated in oncogene-transformed cultured cells. Overexpression of either initiation factor induces a tumorigenic phenotype in rodent cells. We have shown earlier that expression of both eIF-4E and eIF-2* is increased in non-Hodgkin lymphomas (non-HLs). In this study, we performed an immunohistochemical survey of these translation initiation factors in neoplastic cells of HL. We also used Western blot to addressed the possibility that eIF-4E increases expression of NFkappaB. Our results indicate that both eIF-4E and eIF-2* are strongly expressed in neoplastic cells of HL in most cases examined as compared with weak or undetectable expression in most surrounding lymphocytes. An increase in eIF-4E expression may lead to constitutively high expression of NFkappaB, a transcription factor implicated in resistance to apoptosis and induction of cytokine gene expression in various cells, including neoplastic cells of HL.

    PMID:
    18234281
    [PubMed - indexed for MEDLINE]

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