Phys Rev Lett. 2007 Nov 23;99(21):218103. Epub 2007 Nov 21.

Experiments confirm the influence of genome long-range correlations on nucleosome positioning.

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Laboratoire Joliot-Curie and Laboratoire de Physique, CNRS, ENS-Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France.

Abstract

From the statistical analysis of nucleosome positioning data for chromosome III of S. cerevisiae, we demonstrate that long-range correlations (LRC) in the genomic sequence strongly influence the organization of nucleosomes. We present a physical explanation of how LRC may significantly condition the overall formation and positioning of nucleosomes including the nucleosome-free regions observed at gene promoters. From grand canonical Monte Carlo simulations based upon a simple sequence-dependent nucleosome model, we show that LRC induce a patchy nucleosome occupancy landscape with alternation of "crystal-like" phases of confined regularly spaced nucleosomes and "fluidlike" phases of rather diluted nonpositioned nucleosomes.

PMID:: 18233262; [PubMed - indexed for MEDLINE]

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