Braz J Med Biol Res. 1991;24(4):421-4.

An aqueous extract of guaraná (Paullinia cupana) decreases platelet thromboxane synthesis.

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Fundação Pró-Sangue Hemocentro de São Paulo, Faculdade de Medicina, Universidade de São Paulo, Brasil.

Abstract

The effects of an aqueous extract of guaraná (Paullinia cupana) on rabbit platelet aggregation and thromboxane synthesis were examined. The guaraná extract (100 mg/ml) and fractions separated by TLC (origin and xanthines) decreased platelet aggregation (37, 27 and 31% of control values, respectively) and platelet thromboxane formation from [14C]-arachidonic acid (78, 70 and 50% of control values, respectively). The decreased thromboxane synthesis could be responsible, at least in part, for the antiaggregatory action of guaraná.

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Cited by 1 PubMed Central article

Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats. [Evid Based Complement Alternat...]
Herb-Drug Interaction of Paullinia cupana (Guarana) Seed Extract on the Pharmacokinetics of Amiodarone in Rats.
Rodrigues M, Alves G, Lourenço N, Falcão A. Evid Based Complement Alternat Med. 2012; 2012:428560. Epub 2012 Dec 5.

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