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1: Hepatogastroenterology. 1991 Dec;38 Suppl 1:83-6.Links

Treatment of high-output gastric fistulas with omeprazole.

Deruyter L, Van Blerk M, Cadière GB, De Graef J, Willems G.

Department of Surgery, Academic Hospital, Free University Brussels, Belgium.

Two patients with high-output gastrocutaneous fistulas were treated with total parenteral nutrition and gastric antisecretory drugs. IV administration of omeprazole decreased acid output in one patient in a rapid and significant way, resulting in the spontaneous healing of the fistula after eight days of treatment. In the second patient, omeprazole caused a marked reduction in the acidity of the fluid in the fistula, which also closed without surgical operation. The long-standing decrease in acid output induced by intravenous omeprazole may be very useful for promoting spontaneous closure of high-output gastrocutaneous fistula.

PMID: 1823072 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Total Parenteral Nutrition

    Your doctor has ordered total parenteral nutrition (TPN) for you. TPN will drip through a needle or catheter placed in your vein for 10-12 hours, once a day or five times a week.

  • Esomeprazole (Nexium® )

    Esomeprazole is used to treat gastroesophageal reflux disease (GERD), a condition in which backward flow of acid from the stomach causes heartburn and injury of the esophagus (food pipe between the mouth and stomach) in ...

  • Omeprazole (Prilosec® , Prilosec® OTC, Zegerid® )

    Prescription omeprazole is used alone or with other medications to treat ulcers (sores in the lining of the stomach or small intestine); gastroesophageal reflux disease (GERD), a condition in which backward flow of acid ...

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